The Ultimate Guide to 17-alpha Methyltestosterone for Fish
17-alpha methyltestosterone (17α-MT) is a synthetic anabolic steroid widely used in aquaculture to manipulate the sex of fish, particularly in species like rainbow trout and Atlantic salmon. This guide aims to provide a comprehensive overview of this powerful hormone, its applications, dosages, and safety considerations, helping aquaculture professionals and researchers to make informed decisions.
Comparison Table of 17-alpha Methyltestosterone Types and Applications
| Type | Application | Dosage for Rainbow Trout | Dosage for Atlantic Salmon | Manufacturer |
|---|---|---|---|---|
| 17α-Methyltestosterone Powder | Inducing sex reversal | 10.8 mg active drug/kg fish biomass | 6.3 mg active drug/kg fish biomass | Rangen Inc. (www.fws.gov) |
| 17α-Methyltestosterone ELISA Kit | Testing and research | N/A | N/A | MyBioSource (www.mybiosource.com) |
| 17α-Methyltestosterone for Research | Cognitive effect studies | N/A | N/A | AbMole (www.abmole.com) |
| 17α-Methyltestosterone for Aquaculture | Hormone treatment in fish farming | 3 mg MET/kg feed (60 days) | 1 mg MET/kg feed (105 days) | Crescent Chemical (crescentchemical.com) |
What is 17-alpha Methyltestosterone?
17-alpha methyltestosterone is a synthetic androgen that is primarily used in aquaculture to induce sex reversal in fish. This hormone is particularly effective in producing masculinized females that can produce sperm, which is crucial for breeding programs. The hormone works by mimicking testosterone and has been shown to be effective in various fish species.
How Does 17-alpha Methyltestosterone Work?
The mechanism of action of 17α-MT involves binding to androgen receptors in target tissues, leading to the development of male characteristics. In fish, this can result in changes in growth rates, reproductive capabilities, and overall health. By carefully controlling the dosage and duration of treatment, aquaculturists can effectively manage fish populations and enhance breeding outcomes.
Applications in Aquaculture
Sex Reversal
The primary application of 17α-MT in aquaculture is for sex reversal. By administering the hormone during specific developmental stages, typically in the larval phase, fish can be induced to develop male traits. This is particularly beneficial in species where males are more desirable for breeding or growth.
Growth Promotion
In addition to sex reversal, 17α-MT can also promote growth in fish. Higher growth rates can be achieved through the hormonal manipulation of metabolic pathways, leading to increased feed conversion efficiency. This is especially significant in commercial fish farming, where maximizing yield is critical.
Research Purposes
Researchers utilize 17α-MT to study various physiological and behavioral effects in fish. This includes investigations into cognitive functions, stress responses, and the long-term impacts of hormonal treatments. Studies conducted using 17α-MT provide valuable insights into fish biology and aquaculture practices.
Dosage Guidelines
For Rainbow Trout
The recommended dosage for rainbow trout is 10.8 mg of active drug per kg of fish biomass. This is typically incorporated into feed at a rate of 3 mg MET per kg of feed, administered over a 60-day period. The careful monitoring of fish behavior and health during this period is critical to ensure effective treatment.
For Atlantic Salmon
For Atlantic salmon, the recommended dosage is slightly lower at 6.3 mg of active drug per kg of fish biomass. The feed should contain 1 mg MET per kg, and the treatment duration is 105 days. As with rainbow trout, monitoring is essential to assess the efficacy and safety of the treatment.
Safety and Environmental Considerations
The use of 17α-MT is subject to strict regulations due to potential environmental impacts. The FDA requires all participants in the investigational new animal drug (INAD) program to be approved, ensuring that treatments are conducted safely and effectively. Furthermore, reports on fish behavior and any adverse effects must be documented and submitted.
Toxicity Studies
Research has indicated that while 17α-MT can be effective, it also poses risks to ecosystems. Studies involving zebrafish have shown that exposure to varying concentrations of the hormone can lead to genotoxic effects and alter enzymatic activities. Therefore, responsible use and thorough research are imperative to mitigate these risks.
Technical Features of 17-alpha Methyltestosterone
| Feature | Description |
|---|---|
| Chemical Structure | Alkylated at C-17 |
| Purity | 99.9% in research applications |
| Safety Classification | Class III Anabolic Androgen Steroid |
| Mode of Action | Androgen receptor agonist |
| Application Method | Incorporated into feed |
Related Video
Conclusion
17-alpha methyltestosterone is a powerful tool in the field of aquaculture, offering significant benefits in sex reversal and growth promotion. However, its use must be carefully managed to ensure safety and compliance with regulatory standards. By understanding the applications, dosages, and potential risks associated with 17α-MT, aquaculture professionals can leverage this hormone to enhance their operations while minimizing environmental impact.
FAQ
What is 17-alpha methyltestosterone used for?
17-alpha methyltestosterone is primarily used in aquaculture to induce sex reversal in fish and promote growth.
How does 17-alpha methyltestosterone affect fish?
It mimics testosterone, leading to the development of male traits and increased growth rates when administered at the correct dosage.
What are the recommended dosages for rainbow trout?
For rainbow trout, a dosage of 10.8 mg active drug per kg of fish biomass is recommended, with feed containing 3 mg MET per kg over a span of 60 days.
What are the recommended dosages for Atlantic salmon?
For Atlantic salmon, the dosage is 6.3 mg active drug per kg of fish biomass, with feed containing 1 mg MET per kg for 105 days.
Are there any risks associated with using 17-alpha methyltestosterone?
Yes, there are potential risks, including genotoxic effects and alterations in enzymatic activities, necessitating careful monitoring during treatment.
Is there a withdrawal period for fish treated with 17-alpha methyltestosterone?
Yes, there is an investigational withdrawal period of 120 days after treatment.
Can 17-alpha methyltestosterone be used for human consumption?
No, 17-alpha methyltestosterone is not approved for human consumption and is intended solely for research and aquaculture applications.
How is 17-alpha methyltestosterone incorporated into fish feed?
It is typically mixed into the feed at specified concentrations to ensure accurate dosing during the treatment period.
What organizations regulate the use of 17-alpha methyltestosterone?
The use of 17-alpha methyltestosterone is regulated by the FDA and requires participation in the INAD program for safety and environmental compliance.
Where can I find 17-alpha methyltestosterone for purchase?
It can be sourced from various suppliers, including Rangen Inc., Crescent Chemical, and AASraw, among others.