The Ultimate Guide to Pagoclone: Research Chemical Insights

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Pagoclone, a non-benzodiazepine anxiolytic drug, has garnered significant attention within the research community due to its potential therapeutic effects. As a member of the cyclopyrrolone family, Pagoclone serves as an analogue of the well-known sleeping aid, zopiclone. This guide aims to provide a comprehensive overview of Pagoclone, including its applications, advantages, and comparisons with similar compounds, ultimately offering a valuable resource for researchers and enthusiasts alike.

Pagoclone Comparison Table

Type Form Dosage Purity Price Range Application
Pagoclone Pellets 10 mg >99% $16.95 – $423.50 Anxiolytic research, cognitive enhancement
Pagoclone Powder N/A >97% $60.00 – $120.00 Lab experiments, pharmacological studies
Pagoclone Strips 10 mg >97% €16.95 – €237.50 Controlled studies on GABA_A receptor activity
Pagoclone Capsules 10 mg >99% Varies Anxiolytic effects, sedation research

Understanding Pagoclone

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Pagoclone (CAS Number: 133737-32-3) is a synthetic compound designed to interact with the GABA_A receptors in the brain. Structurally related to zopiclone and eszopiclone, it has been researched for its potential to alleviate anxiety without the sedative side effects commonly associated with benzodiazepines. This selectivity makes Pagoclone particularly interesting for scientific studies focused on anxiety disorders.

Mechanism of Action

Pagoclone functions primarily as a partial agonist at the GABA_A receptors, specifically affecting subtypes α1, α2, α3, α5, while acting as a full agonist at the α3 subtype. This unique interaction profile may contribute to its anxiolytic properties while minimizing sedation—a significant advantage over traditional anxiolytics.

Benefits of Using Pagoclone

Pagoclone ((+)-RP-59037) | GABAA Agonist | MedChemExpress

  1. Reduced Sedation: Pagoclone’s selective action on GABA_A receptors may lead to fewer sedative effects, making it suitable for research where alertness is crucial.
  2. Cognitive Enhancement: Some studies suggest that Pagoclone may improve cognitive functions, which can be beneficial in exploring treatments for cognitive impairments.
  3. Research Applications: The compound is ideal for various research applications, including pharmacological studies and the investigation of anxiety disorders.

Applications of Pagoclone

Pagoclone has several potential applications in research settings, each contributing to a deeper understanding of its effects and mechanisms.

Anxiolytic Research

Pagoclone is primarily explored for its anxiolytic properties. Researchers are investigating its effectiveness in alleviating anxiety symptoms without the associated risks of addiction or sedation found in traditional benzodiazepines. Research institutions like those using supplies from teamchemists.com are actively studying this aspect.

Cognitive Enhancement Studies

Due to its unique properties, Pagoclone is being examined for its potential to enhance cognitive functions. Studies are ongoing to determine its efficacy in improving memory and learning capabilities, making it a promising candidate for future cognitive enhancement therapies.

Neuropharmacological Research

Researchers are leveraging Pagoclone’s specific GABA_A receptor interactions to understand better the neuropharmacological basis of anxiety and related disorders. This line of research may pave the way for new anxiolytic medications with improved safety profiles.

Technical Comparison Table

Feature Pagoclone (teamchemists.com) Pagoclone (medeusresearchchem.com) Pagoclone (doctorlab.nl)
CAS Number 133737-32-3 133737-32-3 185825-16-8
Molecular Formula C17H16ClN5O3 C17H16ClN5O3 C17H16ClN5O3
Molar Mass 407.9 g/mol 407.9 g/mol 381.8 g/mol
Purity >99% >99% >97%
Price $23.00 $16.95 – $229.95 €16.95 – €423.50

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Conclusion

Pagoclone stands out as a valuable research chemical with potential applications in anxiety treatment and cognitive enhancement. Its unique properties, including reduced sedation and selective GABA_A receptor interaction, make it a compelling subject for ongoing scientific studies. As researchers continue to explore its benefits, Pagoclone may pave the way for innovative therapeutic approaches in the field of mental health.

FAQ

What is Pagoclone?
Pagoclone is a non-benzodiazepine anxiolytic drug that acts on GABA_A receptors, specifically designed for research purposes. It is structurally related to zopiclone and is explored for its potential to alleviate anxiety.

How does Pagoclone work?
Pagoclone functions as a partial agonist at various GABA_A receptor subtypes, which may help reduce anxiety without causing significant sedation.

Where can I buy Pagoclone?
Pagoclone can be purchased from various suppliers like teamchemists.com, medeusresearchchem.com, and doctorlab.nl, among others.

What are the common forms of Pagoclone available?
Pagoclone is available in several forms, including pellets, powders, capsules, and strips, each designed for specific research applications.

Is Pagoclone safe for human consumption?
Pagoclone is a research chemical intended for laboratory use only and is not approved for human consumption. It should only be handled by qualified researchers.

What are the potential side effects of Pagoclone?
While Pagoclone is designed to minimize sedation and other side effects, research is ongoing to fully understand its safety profile and any potential adverse effects.

What is the typical purity level of Pagoclone?
Most suppliers offer Pagoclone with a purity level exceeding 97%, ensuring high-quality material for research purposes.

Can Pagoclone be used for cognitive enhancement?
Yes, studies are investigating Pagoclone’s potential for cognitive enhancement, particularly in improving memory and learning.

What research applications does Pagoclone have?
Pagoclone is primarily used in anxiolytic research, cognitive enhancement studies, and neuropharmacological investigations.

How should Pagoclone be stored?
Pagoclone should be stored in a cool, dry place, away from direct sunlight and moisture, to maintain its integrity for research purposes.