Looking for the best factor 8 name factories but not sure where to start? Choosing the right one can make all the difference in quality and reliability. Discover the benefits of knowing your top options. Read on to find out which factories truly stand out from the rest!
Clotting Factors List, Functions, Blood Clot and Embolus
Product Details: The blood clotting system involves platelets, fibrinogen, clotting factors, and other blood components that work together to form a clot and stop bleeding following vessel injury. The process is mediated by a sequence of clotting factors that activate each other in a cascade to ultimately produce a stable, cross-linked fibrin network.
Technical Parameters:
– Clotting factors include Factor I (Fibrinogen), Factor II (Prothrombin), Factor…
– The coagulation cascade consists of intrinsic and extrinsic pathways, leading to…
Application Scenarios:
– Sealing damaged blood vessels to prevent blood loss during injury.
– Clinical management and diagnosis of bleeding disorders such as Hemophilia A, B,…
Pros:
– Effectively prevents excessive blood loss by sealing injured blood vessels.
– Involves a well-regulated cascade that localizes clot formation to damaged areas…
Cons:
– Formation of clots inside blood vessels without injury (thrombosis) can lead to…
– Deficiencies or dysfunction in clotting factors can result in bleeding disorders…
Factor VIII (Antihemophilic factor) – Lab Tests Guide
Product Details: Factor VIII (FVIII), also known as antihemophilic factor (AHF), is an essential protein for blood clotting. It is encoded by the F8 gene, and its deficiency leads to hemophilia A, an X-linked recessive coagulation disorder. Factor VIII levels are measured to evaluate coagulation defects or monitor treatment in patients with bleeding disorders or prolonged bleeding.
Technical Parameters:
– Sample required: 5 ml venous blood with sodium citrate anticoagulant; plasma tes…
– Normal value: Factor VIII (Antihemophilic factor) = 30 mg/dL
Application Scenarios:
– Diagnosing inherited or acquired bleeding disorders, especially hemophilia A.
– Monitoring treatment effectiveness in patients with coagulation factor deficienc…
Pros:
– Supports diagnosis and management of bleeding disorders.
– Helps assess severity and monitor therapy in factor deficiency patients.
Cons:
– Requires proper handling and timely processing of blood samples for accurate res…
– Interpretation of results may be complex and should be done by qualified healthc…
F8 gene – MedlinePlus
Product Details: The F8 gene provides instructions for making coagulation factor VIII, a protein essential for blood clot formation. This protein is produced mainly in the liver and circulates in the bloodstream in an inactive form, becoming active upon injury to facilitate the blood coagulation cascade.
Technical Parameters:
– Protein: Coagulation factor VIII (also referred to as AHF, antihemophilic factor…
– Genetic mutations: Over 1,300 identified mutations including base pair substitut…
Application Scenarios:
– Used in physiological blood clotting processes to prevent excessive bleeding aft…
– Relevant in the diagnosis and treatment of hemophilia A, a bleeding disorder cau…
Pros:
– Essential role in the blood clotting cascade and prevention of excessive blood l…
– Provides a target for replacement therapy in patients with hemophilia A
Cons:
– Mutations or deficiencies lead to impaired clotting and excessive bleeding, as s…
– Large gene inversions or severe mutations may result in very low or absent activ…
Content – Health Encyclopedia – University of Rochester Medical Center
Product Details: The Factor VIII (Antihemophilia Factor A) test measures the activity of factor VIII, a blood-clotting protein, to diagnose hemophilia A or other clotting disorders.
Technical Parameters:
– Test results are reported as a percentage of normal factor VIII activity (normal…
– Blood sample collected via venipuncture; may be influenced by medications such a…
Application Scenarios:
– Diagnosis of hemophilia A in individuals with a family history or with symptoms…
– Screening as part of broader coagulation studies or when abnormal clotting test…
Pros:
– Enables specific diagnosis of hemophilia A and other factor VIII related disorde…
– Can be used alongside other tests to provide comprehensive clotting profile
Cons:
– Results may be affected by certain medications like NSAIDs
– Requires blood draw, which may cause discomfort or minor complications such as b…
AHF (Antihemophilic Factor): Uses & Side Effects – Cleveland Clinic
Product Details: Antihemophilic Factor (AHF or Factor VIII) is a medication used to prevent or control bleeding in patients with hemophilia A and, in some cases, to treat von Willebrand’s disease. It is administered by intravenous injection and is available under various brand names, such as Advate, AFSTYLA, Alphanate, among others. It may be derived from human plasma or produced recombinantly.
Technical Parameters:
– Administered by intravenous injection
– Most products are stored in a refrigerator between 2 and 8 degrees Celsius (36 a…
Application Scenarios:
– Prevention or control of bleeding episodes in patients with hemophilia A
– Management of bleeding during surgical procedures in patients with hemophilia A;…
Pros:
– Effective in controlling and preventing bleeding in hemophilia A
– Suitable for both hospital/clinic use and home administration with proper traini…
Cons:
– Risk of allergic reactions and possible viral/bacterial contamination in plasma-…
– Requires intravenous administration and careful storage; may have side effects s…
Factor VIII (Human Plasma): Hemophilia Uses, Side Effects – MedicineNet
Factor VIII: structure and function in blood clotting – PubMed
Product Details: Factor VIII (antihemophilic factor) is a plasma protein involved in blood clotting, deficient or defective in patients with classical hemophilia and Von Willebrand syndrome. In plasma, Factor VIII is associated with high molecular weight multimers of Von Willebrand protein and plays a critical role in promoting the activation of factor X by factor IXa.
Technical Parameters:
– Molecular weight (Mr) of purified human factor VIII: 200,000–300,000, consisting…
– Plasma concentration: 100–200 ng/ml (~1 nM)
Application Scenarios:
– Used in the management and treatment of bleeding disorders such as classical hem…
– Applied in research to understand and address inherited blood clotting abnormali…
Pros:
– Essential for optimal blood clotting through acceleration of factor IXa-mediated…
– Multiple regulatory mechanisms: can be activated, inactivated, and modulated by…
Cons:
– Deficiency or defects lead to serious clinical conditions such as hemophilia and…
– Uncertainty regarding the exact mechanism of activation and requirement for prot…
Factor VIII – Hemostasis.com
Factor VIII (Antihemophilia Factor A) – Brigham and Women’s Hospital
Product Details: The Factor VIII (Antihemophilic Factor A) test measures the activity of factor VIII, a blood-clotting protein. It is used to diagnose hemophilia A or other clotting disorders.
Technical Parameters:
– Reports results as a percentage of ‘normal’ (100%), with normal ranges typically…
– Blood sample is required; factor VIII activity level <50% may indicate hemophili…
Application Scenarios:
– Diagnosis of hemophilia A and investigation of unexplained bleeding or easy brui…
– Used with other tests (e.g., PTT, PT, platelet count, von Willebrand factor test…
Pros:
– Helps accurately diagnose hemophilia A and distinguish from other bleeding disor…
– Can guide proper treatment and genetic counseling for affected individuals and c…
Cons:
– Blood draw carries minor risks such as bleeding, infection, bruising, and lighth…
– Test results may be affected by medications (aspirin, NSAIDs) and individual lab…
Recombinate (factor VIII): Uses, Side Effects, Dosage & Reviews – GoodRx
Product Details: Recombinate (factor VIII) is a prescription coagulation (clotting) factor replacement medication used to prevent and control bleeding in people with hemophilia A (factor VIII deficiency). It is administered intravenously and is made in a laboratory using recombinant DNA technology, not derived from human blood products.
Technical Parameters:
– Administered as intravenous (IV) infusion
– Available only as brand name with no lower-cost generic
Application Scenarios:
– Prevention and treatment of bleeding episodes in patients with hemophilia A
– Prevention of bleeding during surgical procedures in people with hemophilia A
Pros:
– Effectively prevents and treats bleeding in people with hemophilia A
– Lab-made product, so it carries no risk of viral infections associated with huma…
Cons:
– Only available as an IV infusion
– Brand name only and can be expensive; not approved for routine prevention (only…
Related Video
Comparison Table
| Company | Product Details | Pros | Cons | Website |
|---|---|---|---|---|
| Clotting Factors List, Functions, Blood Clot and Embolus | The blood clotting system involves platelets, fibrinogen, clotting factors, and other blood components that work together to form a clot and stop blee… | – Effectively prevents excessive blood loss by sealing injured blood vessels. – Involves a well-regulated cascade that localizes clot formation to dam… | – Formation of clots inside blood vessels without injury (thrombosis) can lead to… – Deficiencies or dysfunction in clotting factors can result in b… | healthhype.com |
| Factor VIII (Antihemophilic factor) – Lab Tests Guide | Factor VIII (FVIII), also known as antihemophilic factor (AHF), is an essential protein for blood clotting. It is encoded by the F8 gene, and its defi… | – Supports diagnosis and management of bleeding disorders. – Helps assess severity and monitor therapy in factor deficiency patients. | – Requires proper handling and timely processing of blood samples for accurate res… – Interpretation of results may be complex and should be done by… | www.labtestsguide.com |
| F8 gene – MedlinePlus | The F8 gene provides instructions for making coagulation factor VIII, a protein essential for blood clot formation. This protein is produced mainly in… | – Essential role in the blood clotting cascade and prevention of excessive blood l… – Provides a target for replacement therapy in patients with hem… | – Mutations or deficiencies lead to impaired clotting and excessive bleeding, as s… – Large gene inversions or severe mutations may result in very l… | medlineplus.gov |
| Content – Health Encyclopedia – University of Rochester Medical Center | The Factor VIII (Antihemophilia Factor A) test measures the activity of factor VIII, a blood-clotting protein, to diagnose hemophilia A or other clott… | – Enables specific diagnosis of hemophilia A and other factor VIII related disorde… – Can be used alongside other tests to provide comprehensive clo… | – Results may be affected by certain medications like NSAIDs – Requires blood draw, which may cause discomfort or minor complications such as b… | www.urmc.rochester.edu |
| AHF (Antihemophilic Factor): Uses & Side Effects – Cleveland Clinic | Antihemophilic Factor (AHF or Factor VIII) is a medication used to prevent or control bleeding in patients with hemophilia A and, in some cases, to tr… | – Effective in controlling and preventing bleeding in hemophilia A – Suitable for both hospital/clinic use and home administration with proper traini…. | – Risk of allergic reactions and possible viral/bacterial contamination in plasma-… – Requires intravenous administration and careful storage; may h… | my.clevelandclinic.org |
| Factor VIII (Human Plasma): Hemophilia Uses, Side Effects – MedicineNet | www.medicinenet.com | |||
| Factor VIII: structure and function in blood clotting – PubMed | Factor VIII (antihemophilic factor) is a plasma protein involved in blood clotting, deficient or defective in patients with classical hemophilia and V… | – Essential for optimal blood clotting through acceleration of factor IXa-mediated… – Multiple regulatory mechanisms: can be activated, inactivated,… | – Deficiency or defects lead to serious clinical conditions such as hemophilia and… – Uncertainty regarding the exact mechanism of activation and re… | pubmed.ncbi.nlm.nih.gov |
| Factor VIII – Hemostasis.com | www.hemostasis.com | |||
| Factor VIII (Antihemophilia Factor A) – Brigham and Women’s Hospital | The Factor VIII (Antihemophilic Factor A) test measures the activity of factor VIII, a blood-clotting protein. It is used to diagnose hemophilia A or… | – Helps accurately diagnose hemophilia A and distinguish from other bleeding disor… – Can guide proper treatment and genetic counseling for affected… | – Blood draw carries minor risks such as bleeding, infection, bruising, and lighth… – Test results may be affected by medications (aspirin, NSAIDs)… | healthlibrary.brighamandwomens.org |
| Recombinate (factor VIII): Uses, Side Effects, Dosage & Reviews – GoodRx | Recombinate (factor VIII) is a prescription coagulation (clotting) factor replacement medication used to prevent and control bleeding in people with h… | – Effectively prevents and treats bleeding in people with hemophilia A – Lab-made product, so it carries no risk of viral infections associated with h… | – Only available as an IV infusion – Brand name only and can be expensive; not approved for routine prevention (only… | www.goodrx.com |
Frequently Asked Questions (FAQs)
What is Factor 8 and why is it important in factories?
Factor 8 is a protein essential for blood clotting. In factories, especially those focused on biotechnology and pharmaceuticals, Factor 8 is produced for patients with hemophilia A, a condition where this protein is lacking. By manufacturing Factor 8, factories help ensure a steady supply for life-saving treatments.
How is Factor 8 produced in factories?
You’ll find that most modern factories use recombinant DNA technology to produce Factor 8. This involves inserting the gene responsible for Factor 8 into cells, which then create the protein. The process is carefully controlled to ensure purity and effectiveness of the final product.
Are Factor 8 products from factories safe to use?
Yes, Factor 8 made in specialized factories undergoes rigorous testing to ensure safety and quality. Factories adhere to strict guidelines, using advanced purification and quality control processes, so you can trust the products are safe for medical use.
Who benefits from Factor 8 produced in factories?
People with hemophilia A benefit the most. If you or a loved one has this condition, you rely on these products to prevent or manage bleeding episodes, improve quality of life, and reduce complications related to clotting issues.
Can I visit a Factor 8 factory to learn more about production?
While most factories restrict public visits due to safety and confidentiality, some companies may offer virtual tours or educational materials online. If you’re interested, you can reach out to the manufacturer for information or see if they offer any special events or programs.
